Copper-free click--a promising tool for pre-targeted PET imaging.
نویسندگان
چکیده
The copper-free click (CFC) reaction has been evaluated for its potential application to in vivo pre-targeting for PET imaging. A promising biodistribution profile is demonstrated when employing [(18)F]2-fluoroethylazide ([(18)F]1) and optimisation of the CFC reaction with a series of cyclooctynes shows that reactions proceed efficiently with tantalizing opportunities for application-specific tuning.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 7 شماره
صفحات -
تاریخ انتشار 2012